gracillin

Names

[ CAS No. ]:
19083-00-2

[ Name ]:
gracillin

[Synonym ]:
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->3)]-
(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->3)]-β-D-glucopyranoside

Biological Activity

[Description]:

Gracillin is a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica with antitumor agent.Gracillin could induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells.[1]

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

Natural Products >> Terpenoids and Glycosides

[References]

[1]. Chen CR et al. Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1. Pharmazie. 2015 Mar;70(3):199-204.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
290-293℃ (DEC.)

[ Molecular Formula ]:
C₄₅H₇₂O₁₇

[ Molecular Weight ]:
885.043

[ Exact Mass ]:
884.476929

[ PSA ]:
255.91000

[ LogP ]:
4.41

[ Index of Refraction ]:
1.623

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
3077.0

[ Hazard Class ]:
9.0

[ HS Code ]:
29329990