BDA-366

Names

[ CAS No. ]:
1909226-00-1

[ Name ]:
BDA-366

[Synonym ]:
9,10-Anthracenedione, 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-oxiranylmethyl]amino]-
BDA-366
1-{[(2S)-3-(Diethylamino)-2-hydroxypropyl]amino}-4-{[(2S)-2-oxiranylmethyl]amino}-9,10-anthraquinone

Biological Activity

[Description]:

BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Bcl-2:3.3 nM (Ki)

[References]

[1]. Han B, Park D, Li R, et al. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015;27(6):852-863.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
669.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₉N₃O₄

[ Molecular Weight ]:
423.50

[ Flash Point ]:
358.6±31.5 °C

[ Exact Mass ]:
423.215820

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.665

[ Storage condition ]:
-20℃

BDA-366

Names

Biological Activity

Chemical & Physical Properties

Related Compounds