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RWJ 63556

Names

[ CAS No. ]:
190967-35-2

[ Name ]:
RWJ 63556

[Synonym ]:
Methanesulfonamide, N-[5-(4-fluorophenoxy)-2-thienyl]-
N-[5-(4-Fluorophenoxy)-2-thienyl]methanesulfonamide

Biological Activity

[Description]:

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Research Areas >> Inflammation/Immunology

[Target]

COX-2

5-Lipoxygenase


[In Vitro]

RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].

[In Vivo]

RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].

[References]

[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101.

[2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9.


[Related Small Molecules]

U73122 | 4-Acetamidophenol | Aspirin | Zileuton | Paradol | Ginsenoside Rg3 | Ginsenoside Compound K | Xanthohumol | Ibuprofen | Diclofenac | ML355 | NS-398 | Meloxicam | Nordihydroguaiaretic acid | Flufenamic Acid

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
403.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H10FNO3S2

[ Molecular Weight ]:
287.330

[ Flash Point ]:
197.8±31.5 °C

[ Exact Mass ]:
287.008606

[ LogP ]:
4.22

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.624

[ Storage condition ]:
2-8℃

Related Compounds