WRG-28

Names

[ CAS No. ]:
1913291-02-7

[ Name ]:
WRG-28

Biological Activity

[Description]:

WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Discoidin Domain Receptor

[Target]

DDR2:230 nM (IC50)

[References]

[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈N₂O₅S

[ Molecular Weight ]:
410.44

Safety Information

[ Hazard Codes ]:
Xi

WRG-28

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds