Pristane

Names

[ CAS No. ]:
1921-70-6

[ Name ]:
Pristane

[Synonym ]:
Norphytan
2,6,10,10-Tetramethylpentadecane
2,4-DIPHENYL-6-(4'-METHOXYPHENYL)PYRYLIUM PERCHLORATE
2,6,10,14-Tetramethylpentadecane
Pristane
Pristan
Pentadecane, 2,6,10,14-tetramethyl-
MFCD00008952
EINECS 217-650-8
Norphytane
Bute hydrocarbon
UNII-26HZV48DT1
Pentadecane,2,6,10,14-tetramethyl
2,6,10,14-tetramethyl pentadecane

Biological Activity

[Description]:

Pristane (Norphytane) is a naturally occurring hydrocarbon oil found in small quantities in many plants, in various marine organisms, and as the most active component of mineral oil[1]. Pristane is a non-antigenic adjuvant, and induces MHC class II-restricted, arthritogenic T cells in the rat[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Pristane activates CD4+ αβT cells that are MHC class II restricted and arthritogenic[1].

[In Vivo]

Pristane activates CD4+ alpha beta T cells that are MHC class II restricted and arthritogenic in vivo[2]. Animal Model: Naive recipient rats (DA)[2] Dosage: 500 μL of Pristane oil Administration: Intradermal injection Result: Both CD4+, CD8+ αβT cells and B cells significantly expand in draining lymph nodes until day 6 after injection, whereafter the CD4+ αβT cells continue to expand until day 12 after injection.

[References]

[1]. J J Turner, et al. Krypton Fluoride: Preparation by the Matrix Isolation Technique. Science. 1963 May 31;140(3570):974-5.

[2]. Jens Holmberg,et al. Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat. J Immunol. 2006 Jan 15;176(2):1172-9.

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
296.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-99ºC

[ Molecular Formula ]:
C₁₉H₄₀

[ Molecular Weight ]:
268.521

[ Flash Point ]:
140.7±12.3 °C

[ Exact Mass ]:
268.312988

[ LogP ]:
10.11

[ Appearance of Characters ]:
liquid | Clear colorless

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.436

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RZ1880000

CHEMICAL NAME :: Pentadecane, 2,6,10,14-tetramethyl-

CAS REGISTRY NUMBER :: 1921-70-6

BEILSTEIN REFERENCE NO. :: 1720538

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C19-H40

MOLECULAR WEIGHT :: 268.59

WISWESSER LINE NOTATION :: 1Y1&3Y1&3Y1&3Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - man

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - pig

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,579,1980

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - tumors

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 222,994,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1465 No. of Facilities: 66 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 19599 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RZ1880000

[ HS Code ]:
2901100000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2901100000

[ Summary ]:
2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

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