BIIL-260 hydrochloride

Names

[ CAS No. ]:
192581-24-1

[ Name ]:
BIIL-260 hydrochloride

Biological Activity

[Description]:

BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Research Areas >> Inflammation/Immunology

[Target]

Ki: 1.7 nM (LTB4 receptor)[1]

[In Vitro]

BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM

[References]

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₁ClN₂O₃

[ Molecular Weight ]:
503.03

BIIL-260 hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds