Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone

Names

[ CAS No. ]:
1926163-65-6

[ Name ]:
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone

Biological Activity

[Description]:

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Apoptosis >> Caspase

[Target]

Caspase 3


[References]

[1]. M Kalai, et al. Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death Differ. 2002 Sep;9(9):981-94.  

Chemical & Physical Properties

[ Molecular Formula ]:
C43H45FN4O16

[ Molecular Weight ]:
892.83

Related Compounds