4H-1-Benzopyran-4-one,2-(4-chlorophenyl)-3-hydroxy-

Names

[ CAS No. ]:
19275-70-8

[ Name ]:
4H-1-Benzopyran-4-one,2-(4-chlorophenyl)-3-hydroxy-

[Synonym ]:
4'-chloro-3-hydroxyflavone
3-hydroxy-2-(4-chlorophenyl)-chromen-4(1H)-one
4'-Chloroflavonol
3-hydroxy-2-(4-chlorophenyl)-4H-chromen-4(1H)-one
3-Hydroxy-4'-chloroflavone
2-(4-chlorophenyl)-3-hydroxy-4H-chromen-4-one
4'-chloro-3-flavonol

Biological Activity

[Description]:

Tyrosinase-IN-4 (compound 34) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Li J, et al. Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem. 2021;224:113744.

Chemical & Physical Properties

[ Density]:
1.464g/cm3

[ Boiling Point ]:
416.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₉ClO₃

[ Molecular Weight ]:
272.68

[ Flash Point ]:
205.9ºC

[ Exact Mass ]:
272.02400

[ PSA ]:
50.44000

[ LogP ]:
3.81900

[ Vapour Pressure ]:
1.08E-07mmHg at 25°C

[ Index of Refraction ]:
1.683

4H-1-Benzopyran-4-one,2-(4-chlorophenyl)-3-hydroxy-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds