PQR626

Names

[ CAS No. ]:
1927857-98-4

[ Name ]:
PQR626

Biological Activity

[Description]:

mTOR inhibitor-7 is an orally available, and brain-penetrant mTOR inhibitor extracted from patent WO2017198346A1, compound example 44, has an IC50 of 5 nM for mTOR. mTOR inhibitor-7 can be used for the research of neurological disorder[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Neurological Disease

[Target]

IC50: 5 nM (mTOR)[1]

[In Vitro]

mTOR inhibitor-7 (0.04-5 μΜ; 1 hour) has IC50s of 197 nM and 87 nM for pPKB S473 and pS6 S235/S236, respectively, in-cell western blot. S6 kinase (S6K), S6 ribosomal protein (S6rP) and 4E-binding protein (4E-BP) are prominent downstream effectors of mTOR[1]. Western Blot Analysis[1] Cell Line: A2058 cells Concentration: 0.04 μΜ, 0.08 μΜ, 0.155 μΜ, 0.3125 μΜ, 0.625 μΜ, 1.25 μΜ, 5 μΜ Incubation Time: 1 hour Result: Inhibited mTOR in cell.

[References]

[1]. Denise RAGEOT, et al. Treatment of neurological disorders. WO2017198346A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₇F₂N₇O₂

[ Molecular Weight ]:
435.47