<Suppliers Price>

Co 101244 hydrochloride

Names

[ CAS No. ]:
193356-17-1

[ Name ]:
Co 101244 hydrochloride

[Synonym ]:
4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-, hydrochloride (1:1)
1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidin-4-ol hydrochloride (1:1)
1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)

Biological Activity

[Description]:

Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection[1].

[In Vivo]

Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1].

[References]

[1]. Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H28ClNO3

[ Molecular Weight ]:
377.9

[ Storage condition ]:
-20°C

Related Compounds