DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

Names

[ CAS No. ]:
193475-71-7

[ Name ]:
DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

[Synonym ]:
tno211
dabcyl-(g-abu)-pqgl-e(edans)ak-nh2
mmp substrate iii,fluorogenic
dabcyl-gaba-pro-gln-gly-leu-glu(edans)-ala-lys-nh2
dabcyl-(g-abu)-pro-gln-gly-leu-glu(edans)-ala-lys-nh2
dabcyl-gaba-pqgl-e(edans)-ak-nh2
DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

Biological Activity

[Description]:

TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₃H₈₈N₁₆O₁₄S

[ Molecular Weight ]:
1325.54

[ Exact Mass ]:
1309.63000

[ PSA ]:
459.01000

[ LogP ]:
8.07790