Bis-PEG2-acid

Names

[ CAS No. ]:
19364-66-0

[ Name ]:
Bis-PEG2-acid

[Synonym ]:
3,6-dioxaoctanedioic acid

Biological Activity

[Description]:

Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₄O₆

[ Molecular Weight ]:
206.19300

[ Exact Mass ]:
206.07900

[ PSA ]:
93.06000

[ Storage condition ]:
-20°C

Bis-PEG2-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds