MC-Sq-Cit-PAB-Gefitinib

Names

[ CAS No. ]:
1941168-63-3

[ Name ]:
MC-Sq-Cit-PAB-Gefitinib

Biological Activity

[Description]:

MC-Sq-Cit-PAB-Gefitinib has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Sq-Cit-PAB-Gefitinib is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC

[References]

[1]. FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1.

[2]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₀H₆₁ClFN₁₀O₉

[ Molecular Weight ]:
1000.53

MC-Sq-Cit-PAB-Gefitinib

Names

Biological Activity

Chemical & Physical Properties

Related Compounds