Eliapixant

Names

[ CAS No. ]:
1948229-21-7

[ Name ]:
Eliapixant

Biological Activity

[Description]:

Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[Target]

IC50: 8 nM (P2X3 receptor)[1]

[In Vivo]

Eliapixant can be used for the research of coughs and diabetes complications[1].

[References]

[1]. Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561.

[2]. Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240.

Chemical & Physical Properties

[ Density]:
1.360±0.06 g/cm3(Predicted)

[ Molecular Formula ]:
C₂₂H₂₁F₃N₄O₃S

[ Molecular Weight ]:
478.49

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

Eliapixant

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds