Amino-PEG4-CH2COOH

Names

[ CAS No. ]:
195071-49-9

[ Name ]:
Amino-PEG4-CH2COOH

[Synonym ]:
14-amino-3,6,9,12-tetraoxa-1-tetradecanoic acid
3,6,9,12-Tetraoxatetradecanoic acid,14-amino

Biological Activity

[Description]:

Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₂₁NO₆

[ Molecular Weight ]:
251.27700

[ Exact Mass ]:
251.13700

[ PSA ]:
100.24000

Safety Information

[ Hazard Codes ]:
Xi

Amino-PEG4-CH2COOH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Related Compounds