ACPT-II
Names
Biological Activity
[Description]:
ACPT-II is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects[1][2][3][4][5].
[Related Catalog]:
[References]
[1]. Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29.
[2]. Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.
[3]. Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26(1):99-113.
[4]. Chapman AG, et al. Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424(2):107-13.
[5]. Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57(3):227-34.
Chemical & Physical Properties
[ Molecular Formula ]:
C8H11NO6
[ Molecular Weight ]:
217.18
[ Exact Mass ]:
217.05900
[ PSA ]:
137.92000
Synthetic Route