Mepolizumab

Names

[ CAS No. ]:
196078-29-2

[ Name ]:
Mepolizumab

[Synonym ]:
Mepolizumab
Bosatria

Biological Activity

[Description]:

Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[References]

[1]. Tim Harrison, et al. Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis. Eur Respir J. 2020 Oct 15;56(4):2000151.

[2]. Ian D Pavord, From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases. Allergy. 2022 Mar;77(3):778-797.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₆₆O₁₂

[ Molecular Weight ]:
762.96600

[ Exact Mass ]:
762.45500

[ PSA ]:
203.44000

[ LogP ]:
4.56360

Mepolizumab

Names

Biological Activity

Chemical & Physical Properties

Related Compounds