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XAP 044

Names

[ CAS No. ]:
196928-50-4

[ Name ]:
XAP 044

[Synonym ]:
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-
MFCD00525548
XAP 044
7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
XAP044

Biological Activity

[Description]:

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[References]

[1]. Gee CE, et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014;289(16):10975-10987.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
485.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H9IO4

[ Molecular Weight ]:
380.134

[ Flash Point ]:
247.5±28.7 °C

[ Exact Mass ]:
379.954529

[ LogP ]:
4.61

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.718

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310 + P330

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds