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GAP 26 trifluoroacetate salt

Names

[ CAS No. ]:
197250-15-0

[ Name ]:
GAP 26 trifluoroacetate salt

[Synonym ]:
Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
M.W. 1550.78 C70H107N19O19S
VCYDKSFPISHVR

Biological Activity

[Description]:

Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Gap Junction Protein
Research Areas >> Cardiovascular Disease
Peptides

[Target]

Gap Junction Protein[1]


[In Vitro]

Gap 26 is corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[1]. Gap 26 abolishes the inositol-1,4,5-trisphosphate (InsP3)-triggered ATP response and reduces the ATP release, but has no effect on gap junctional coupling[2].

[References]

[1]. Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110.

[2]. Braet K, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.


[Related Small Molecules]

Tonabersat | GAP-134 (Hydrochloride) | GAP 27 acetate salt

Chemical & Physical Properties

[ Molecular Formula ]:
C70H106N19O19S

[ Molecular Weight ]:
1550.78

[ PSA ]:
657.12000

[ LogP ]:
1.84770

[ Storage condition ]:
2-8℃

Related Compounds