SN 003

Names

[ CAS No. ]:
197801-88-0

[ Name ]:
SN 003

Biological Activity

[Description]:

SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CRFR

Research Areas >> Neurological Disease

[References]

[1]. J S Dileep Kumar, et al. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg Med Chem. 2006 Jun 15;14(12):4029-34.

[2]. Andrzej Wróbel, et al. Inhibition of the CRF1 receptor influences the activity of antidepressant drugs in the forced swim test in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):769-774.

[3]. Simeon J Ramsey, et al. Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo. Br J Pharmacol. 2011 Oct;164(3):992-1007.