P-CAB agent 2

Names

[ CAS No. ]:
1978371-23-1

[ Name ]:
P-CAB agent 2

Biological Activity

[Description]:

P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

P-CAB agent 2 (100 µM) 抑制 hERG 钾通道，抑制率为 86.21%，IC50 值为 18.69 M[1]< /sup>。

[In Vivo]

P-CAB agent 2 (example 1) 抑制组胺 (histamine (HY-B1204)) 诱导的 SD 大鼠胃酸分泌[1]. P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) 无急性毒性，600mg/kg 对 SD 大鼠动物体重无显着影响[1]。 Animal Model: 180-220 g, SPF grade, male SD rats[1] Dosage: 2 mg/kg Administration: P.o.; once Result: Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.

[References]

[1]. YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H25FN2O4S

[ Molecular Weight ]:
432.51

Related Compounds