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TRPA1 Antagonist 1

Names

[ CAS No. ]:
1984825-08-2

[ Name ]:
TRPA1 Antagonist 1

Biological Activity

[Description]:

TRPA1 Antagonist 1 is a methylene phosphate prodrug which converts to its active parent drug, a TRPA1 antagonist with an IC50 of 8 nM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[Target]

IC50: 8 nM (TRPA1)[1]

[References]

[1]. Chen H, et al. Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling. J Med Chem. 2018 Apr 26;61(8):3641-3659.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₀F₆N₅Na₂O₇PS

[ Molecular Weight ]:
713.45

Related Compounds