vincanol

Names

[ CAS No. ]:
19877-89-5

[ Name ]:
vincanol

[Synonym ]:
14,15-dihydro-eburnamenin-14-ol
14-Doxylstearic acid
14-DOXYL-octadecanoic acid
epi-eburnamine

Biological Activity

[Description]:

Vincanol ((-)-Isoeburnamine) is a blocker of voltage-gated Na+ channels. Vincanol blocks Na+ currents with an IC50 value of 40 μM. Vincanol has neuroprotective effect[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[References]

[1]. Erdo SA, et al. Vincamine and vincanol are potent blockers of voltage-gated Na+ channels. Eur J Pharmacol. 1996 Oct 24;314(1-2):69-73.

Chemical & Physical Properties

[ Density]:
1.35 g/cm3

[ Boiling Point ]:
484.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₄N₂O

[ Molecular Weight ]:
296.40700

[ Flash Point ]:
246.8ºC

[ Exact Mass ]:
296.18900

[ PSA ]:
28.40000

[ LogP ]:
3.56320

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.719

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JW4794332

CHEMICAL NAME :: Eburnamenin-14-ol, 14,15-dihydro-, (3-alpha,14-alpha,16-alpha)-

CAS REGISTRY NUMBER :: 19877-89-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H24-N2-O

MOLECULAR WEIGHT :: 296.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2319362