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eCF-309

Names

[ CAS No. ]:
2001571-40-8

[ Name ]:
eCF-309

[Synonym ]:
2-Benzoxazolamine, 5-[4-amino-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-
3-(2-Amino-1,3-benzoxazol-5-yl)-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

[Description]:

eCF309 is a potent and highly selective mTOR inhibitor with remarkably low off-target activities (IC50 = 10-15 nM, both in vitro and in cells)[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer

[References]

[1]. Craig Fraser, et al. eCF309: a potent, selective and cell-permeable mTOR inhibitor. Med. Chem. Commun., 2016, 7, 471-477.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
642.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H21N7O3

[ Molecular Weight ]:
383.404

[ Flash Point ]:
342.4±34.3 °C

[ Exact Mass ]:
383.170593

[ LogP ]:
2.31

[ Appearance of Characters ]:
solid

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.727

[ Storage condition ]:
Store at -20℃

[ Water Solubility ]:
Soluble in DMSO

Related Compounds