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UB 165 fumarate

Names

[ CAS No. ]:
200432-86-6

[ Name ]:
UB 165 fumarate

[Synonym ]:
Compound 401
UB 165 FUMARATE

Biological Activity

[Description]:

UB-165 is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for [3H]-nicotine binding in rat brain[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[In Vitro]

UB-165 刺激 [3H]-多巴胺从纹状体突触释放，EC50 值为 88 nM[1]。

[References]

[1]. Sharples CG, et al. UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci. 2000 Apr 15;20(8):2783-91.  

Chemical & Physical Properties

[ Boiling Point ]:
597.4ºC at 760mmHg

[ Molecular Formula ]:
C17H19ClN2O4

[ Molecular Weight ]:
350.79700

[ Flash Point ]:
315.1ºC

[ Exact Mass ]:
350.10300

[ PSA ]:
99.52000

[ LogP ]:
3.07340

Related Compounds