Epinodosin

Names

[ CAS No. ]:
20086-60-6

[ Name ]:
Epinodosin

[Synonym ]:
5H-5a,8-Methano-11H-cyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7H)-dione, decahydro-10,13-dihydroxy-1,1-dimethyl-7-methylene-, (3aS,5aS,8S,10S,10aS,10bS,13R,13aR)-
(1S,4S,8R,9R,12S,13S,14S,16S)-9,14-Dihydroxy-7,7-dimethyl-17-methylene-3,10-dioxapentacyclo[14.2.1.01,13.04,12.08,12]nonadecane-2,18-dione

Biological Activity

[Description]:

Epinodosin is a diterpenoid. Epinodosin has moderate cytotoxicity against HL-60 cells with IC50 value of 10.4 μM. Epinodosin can be used for the research of inflammatory diseases[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 10.4 μM (HL-60 cells)[1]

[In Vitro]

Epinodosin (化合物3) 对HL-60细胞具有中等的细胞毒性，IC50 值为 10.4 μM[1]。

[References]

[1]. Su-Ping Bai, et al. Two novel ent-kauranoid diterpenoids from Isodon japonica leaves. Planta Med. 2005 Aug;71(8):764-9.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
615.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₆O₆

[ Molecular Weight ]:
362.417

[ Flash Point ]:
222.1±25.0 °C

[ Exact Mass ]:
362.172943

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.602