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Rutundic acid

Names

[ CAS No. ]:
20137-37-5

[ Name ]:
Rutundic acid

[Synonym ]:
(3β)-3,19,23-Trihydroxyurs-12-en-28-oic acid
Rotundic acid
Urs-12-en-28-oic acid, 3,19,23-trihydroxy-, (3β)-

Biological Activity

[Description]:

Rotundic acid, a triterpenoid obtained from I. rotunda, induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt

mTOR

p38 MAPK


[References]

[1]. Roy G, et al. Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways. Front Oncol. 2019 Jun 26;9:545.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
622.8±55.0 °C at 760 mmHg

[ Melting Point ]:
272-274℃

[ Molecular Formula ]:
C30H48O5

[ Molecular Weight ]:
488.699

[ Flash Point ]:
344.5±28.0 °C

[ Exact Mass ]:
488.350189

[ PSA ]:
97.99000

[ LogP ]:
5.75

[ Vapour Pressure ]:
0.0±4.1 mmHg at 25°C

[ Index of Refraction ]:
1.581

[ Storage condition ]:
-20℃

Related Compounds