N33-TEG-COOH

Names

[ CAS No. ]:
201467-81-4

[ Name ]:
N33-TEG-COOH

[Synonym ]:
2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanoic acid
N33-TEG-COOH

Biological Activity

[Description]:

N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units.

[Related Catalog]:

Signaling Pathways >> PROTAC >> PROTAC Linker

Research Areas >> Cancer

[Target]

PROTAC linker[1]

[In Vitro]

N33-TEG-COOH is a long linker extracted from Reference PMID: 26035625, Compound 7. A PROTAC is a heterobifunctional compound that contains two ligands connected by a linker unit. One ligand binds an E3 ubiquitin ligase protein, while the other ligand binds to the target protein of interest, thereby bringing the ligase and the target in close proximity[1].

[References]

[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

[Related Small Molecules]

Boc-C1-PEG2-C4-Cl | Cl-C6-PEG4-O-CH2COOH | Protac linker 5 | PROTAC Linker 2

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₉N₃O₆

[ Molecular Weight ]:
277.27400

[ Exact Mass ]:
277.12700

[ PSA ]:
123.97000

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315

[ Precautionary Statements ]:
P210

[ RIDADR ]:
UN 2398 3 / PGII

N33-TEG-COOH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Precursor & DownStream

Precursor

DownStream

Related Compounds