(Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) trifluoroacetate salt

Names

[ CAS No. ]:
201995-58-6

[ Name ]:
(Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) trifluoroacetate salt

[Synonym ]:
L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-lysyl-L-arginyl-L-leucyl-L-seryl-L-alanyl-L-arginyl- L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-leucinamide
L-Leucinamide, L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-lysyl-L-arginyl-L-leucyl-L-seryl-L-al anyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-

Biological Activity

[Description]:

[K15,R16,L27]VIP(1-7)/GRF(8-27), a VIP1 selective agonist, exhibits IC50 values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP1, rat VIP1, rat VIP2 receptors, respectively[1]. VIP: VASOACTIVE Intestinal Polypeptide.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. P Gourlet, et al. Development of high affinity selective VIP1 receptor agonists. Peptides. 1997;18(10):1539-45.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₄₂H₂₄₀N₄₄O₃₈

[ Molecular Weight ]:
3171.70

[ Exact Mass ]:
3169.820068

[ LogP ]:
-3.86

[ Index of Refraction ]:
1.648