Hydroxygenkwanin

Names

[ CAS No. ]:
20243-59-8

[ Name ]:
Hydroxygenkwanin

[Synonym ]:
3',4',5-Trihydroxy-7-methoxyflavone
5,3',4'-trihydroxy-7-methoxyflavanone
7-O-Methylluteolin
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-
luteolin 7-methyl ester
3',4',5-trihydroxy-7-methoxyflavanone
5,3',4'-Trihydroxy-7-methoxyflavone
2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one
Luteolin 7-methyl ether
luteolin-7-methylether

Biological Activity

[Description]:

Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Hydroxygenkwanin (7-O-Methylluteolin) inhibits C6 glioma cell proliferation in a dose dependent manner[1]. Hydroxygenkwanin induces the cell cycle arrest by flow cytometry and inhibits colony formation ability and cell movement. Hydroxygenkwanin induces cell cycle arrest through p21 activation and causes intrinsic cell apoptosis pathway[2].

[References]

[1]. Wang Y, et al. Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro. Chem Biol Interact. 2013 Nov 25;206(2):346-55.

[2]. Huang YC, et al. Anticancer Effect and Mechanism of Hydroxygenkwanin in Oral Squamous Cell Carcinoma. Front Oncol. 2019 Sep 18;9:911.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
602.7±55.0 °C at 760 mmHg

[ Melting Point ]:
225-227ºC

[ Molecular Formula ]:
C₁₆H₁₂O₆

[ Molecular Weight ]:
300.263

[ Flash Point ]:
230.6±25.0 °C

[ Exact Mass ]:
300.063385

[ PSA ]:
100.13000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.697

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%