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Saponarin

Names

[ CAS No. ]:
20310-89-8

[ Name ]:
Saponarin

[Synonym ]:
Saponaretin-7-O-glucoside
5-hydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-7-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
apigenin-6-C,7-O-diglucoside
7-O-(beta-D-glucosyl)isovitexin
Saponarin
isovitexin-7-O-glucoside

Biological Activity

[Description]:

Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Simeonova R, et al. Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats. Phytomedicine. 2016 May 15;23(5):483-90.

[2]. Seo KH, et al. Saponarin from barley sprouts inhibits NF-κB and MAPK on LPS-induced RAW 264.7 cells. Food Funct. 2014 Nov;5(11):3005-13.

[3]. Seo WD, et al. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5237-42.

Chemical & Physical Properties

[ Density]:
1.723 g/cm3

[ Boiling Point ]:
919.5ºC at 760 mmHg

[ Melting Point ]:
228ºC (dec.)

[ Molecular Formula ]:
C27H30O15

[ Molecular Weight ]:
594.51800

[ Flash Point ]:
305.4ºC

[ Exact Mass ]:
594.15800

[ PSA ]:
260.20000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.728

[ Storage condition ]:
2-8℃

Related Compounds