EDTA-d12

Names

[ CAS No. ]:
203806-08-0

[ Name ]:
EDTA-d12

[Synonym ]:
2,2',2'',2'''-[(H)Ethane-1,2-diyldinitrilo]tetra(H)acetic acid
2,2',2'',2'''-[(H)-1,2-Ethanediyldinitrilo]tetra(H)acetic acid
Ethylenediaminetetraacetic-d12 acid
MFCD00144285
EDTA-d12

Biological Activity

[Description]:

EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9.

[3]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 200745(5):565-76.

[4]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb10(1):58-62.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
614.2±55.0 °C at 760 mmHg

[ Melting Point ]:
250ºC (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₄D₁₂N₂O₈

[ Molecular Weight ]:
304.317

[ Flash Point ]:
325.2±31.5 °C

[ Exact Mass ]:
304.165985

[ PSA ]:
155.68000

[ LogP ]:
-0.43

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.580

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

Metabonomic Changes Associated with Atherosclerosis Progression for LDLR(-/-) Mice.

J. Proteome Res. 14 , 2237-54, (2015)

Atherosclerosis resulting from hyperlipidemia causes many serious cardiovascular diseases. To understand the systems changes associated with pathogenesis and progression of atherosclerosis, we compreh...

Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.

J. Biomol. NMR 50 , 197-207, (2011)

NMR spectroscopic characterization of the structure or the dynamics of proteins generally requires the production of samples isotopically enriched in (15)N, (13)C, or (2)H. The bacterial expression sy...