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RTI 4229-336

Names

[ CAS No. ]:
204069-50-1

[ Name ]:
RTI 4229-336

[Synonym ]:
(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-1,2-oxazol-5-yl]-8-azabicyclo[3.2.1]octane hydrochloride (1:1)
8-Azabicyclo[3.2.1]octane, 3-(4-chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-5-isoxazolyl]-, (1R,2S,3S,5S)-, hydrochloride (1:1)
RTI-336

Biological Activity

[Description]:

RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter
Research Areas >> Neurological Disease

[In Vivo]

RTI 336（3 mg/kg；皮下注射；30 分钟预处理）显著减少 Lewis 大鼠对成瘾剂的输注次数[1]。 RTI 336（3 毫克/千克；腹腔注射；30 分钟预处理）降低 Lewis 大鼠中由成瘾剂诱导的反应率（杠杆按压/秒）[1]。

[References]

[1]. Haile CN, et al. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 7;1055(1-2):186-95.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H26Cl2N2O

[ Molecular Weight ]:
429.38

[ Exact Mass ]:
428.142212

Related Compounds