GSK963

Names

[ CAS No. ]:
2049868-46-2

[ Name ]:
GSK963

[Synonym ]:
(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

Biological Activity

[Description]:

GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase

Research Areas >> Others

[Target]

IC50: 29 nM (RIP1 in FP binding assay)[1].

[References]

[1]. Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.

Chemical & Physical Properties

[ Density]:
1.06±0.1 g/cm3

[ Boiling Point ]:
342.8±45.0 °C

[ Molecular Formula ]:
C₁₄H₁₈N₂O

[ Molecular Weight ]:
230.31

[ Storage condition ]:
-20℃