Diethylene Glycol Monobenzyl Ether

Names

[ CAS No. ]:
2050-25-1

[ Name ]:
Diethylene Glycol Monobenzyl Ether

[Synonym ]:
Ethanol, 2-[2-(phenylmethoxy)ethoxy]-
2-[2-(Benzyloxy)ethoxy]ethanol
Ethanol, 2-[2-(benzyloxy)ethoxy]-
Ethanol, 2-[2- (phenylmethoxy)ethoxy]-
Diethylene Glycol Monobenzyl Ether
MFCD00029649
Ethanol, 2-[2- (benzyloxy)ethoxy]-

Biological Activity

[Description]:

Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
311.2±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₆O₃

[ Molecular Weight ]:
196.243

[ Flash Point ]:
142.0±22.3 °C

[ Exact Mass ]:
196.109940

[ PSA ]:
38.69000

[ LogP ]:
0.90

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.513

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Synthesis and characterization of star poly(epsilon-caprolactone)-b-poly(ethylene glycol) and poly(L-lactide)-b-poly(ethylene glycol) copolymers: evaluation as drug delivery carriers.

Bioconjug. Chem. 19(7) , 1423-9, (2008)

Two types of 32 arm star polymers incorporating amphiphilic block copolymer arms have been synthesized and characterized. The first type, stPCL-PEG 32, is composed of a polyamidoamine (PAMAM) dendrime...