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talatisamine

Names

[ CAS No. ]:
20501-56-8

[ Name ]:
talatisamine

[Synonym ]:
talatizamine
Talatisamine
(1α,14α,16β)-20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol
20-Ethyl-1-α,16-β-dimethoxy-4-(methoxymethyl)aconitane-8,14-α-diol
Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1α,4β,14α,16β)-
(16S)-20-ethyl-1α,16-dimethoxy-4-methoxymethyl-aconitane-8,14α-diol
(16S)-20-Aethyl-1α,16-dimethoxy-4-methoxymethyl-aconitan-8,14α-diol
Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1α,14α,16β)-
(1α,4β,14α,16β)-20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol

Biological Activity

[Description]:

Talatisamine, a aconitum alkaloid，is specific K+ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Wang Y, et al. The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. Neurosci Lett. 2012 Jun 19;518(2):122-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
533.9±50.0 °C at 760 mmHg

[ Melting Point ]:
151-152℃

[ Molecular Formula ]:
C24H39NO5

[ Molecular Weight ]:
421.570

[ Flash Point ]:
276.7±30.1 °C

[ Exact Mass ]:
421.282837

[ PSA ]:
71.39000

[ LogP ]:
-0.50

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
2-8C

Related Compounds