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Nur77 modulator 2

Names

[ CAS No. ]:
2055829-03-1

[ Name ]:
Nur77 modulator 2

Biological Activity

[Description]:

Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

Kd: 0.35 μM (Nur77)[1]


[In Vitro]

Nur77 modulator 2 (Compound B7) significantly decreases the production of cytokines in vitro, such as NO, IL-6, IL-1β, and TNF-α, at concentrations of 1.25 μM, 2.5 μM, and 5 μM. Nur77 modulator 2 inhibits the lipopolysaccharides (LPS)-induced inflammation via the blockade of NF-κB activation in a Nur77-dependent manner[1].

[In Vivo]

Nur77 modulator 2 (Compound B7; 5-10 mg/kg; p.o; for 1 week) shows in vivo anti-inflammatory activity in the LPS-induced mice model of acute lung injury (ALI)[1].

[References]

[1]. Mingtao Ao, et al. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorg Chem. 2022 Jan 29;120:105645.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H25NO5

[ Molecular Weight ]:
431.48

Related Compounds