Benzothiohydrazide

Names

[ CAS No. ]:
20605-40-7

[ Name ]:
Benzothiohydrazide

[Synonym ]:
Benzoic acid,thio-,hydrazide
Thiobenzoylhydrazin
Benzoicacid,thio-,hydrazide (7CI,8CI)
phenylthiohydrazide
thiobenzoylhydrazide
Thiobenzohydrazide
Thiobenzoylhydrazine
Thiobenzoic hydrazide
Benzenecarbothioic acid,hydrazide
Thiobenzhydrazide
thiobenzoic acid hydrazide

Biological Activity

[Description]:

Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC1 and IC2)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. J. Laborde, et al. Synthesis, oxidation potential and anti–mycobacterial activity of isoniazid and analogues: insights into the molecular isoniazid activation mechanism. ChemistrySelect, 1(2), 172–179.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₈N₂S

[ Molecular Weight ]:
152.21700

[ Exact Mass ]:
152.04100

[ PSA ]:
77.18000

[ LogP ]:
1.93700

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%