MS-PPOH
Names
[ CAS No. ]:
206052-02-0
[ Name ]:
MS-PPOH
[Synonym ]:
Benzenehexanamide, N-(methylsulfonyl)-2-propoxy-
N-(Methylsulfonyl)-6-(2-propoxyphenyl)hexanamide
Biological Activity
[Description]:
MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor[1]. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 µM, respectively[2].
[Related Catalog]:
[In Vitro]
MS-PPOH blocks cellular EET synthesis. MS-PPOH inhibits tonic (basal) cell invasion and migration and reduces the 11,12-EET (1.0 μM)-induced cell motility[1]. Cell Viability Assay[1] Cell Line: PC-3 cells Concentration: 2.0 and 10.0 μM Incubation Time: 24 hours Result: Inhibited tonic (basal) cell invasion and migration.
[In Vivo]
MS-PPOH (20 mg/kg/day, i.v.) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on 2% NaCl drinking solution[3]. Animal Model: Six-week-old male stroke-prone spontaneously hypertensive rats (SHRSP)[3] Dosage: 20 mg/kg/day Administration: Intravenously Result: Treatment had negligible effects on systolic blood pressure (SBP) in saline-drinking SHRSP after 1 week, 160 vs. 167 mmHg, or 2 weeks of treatment, 171 vs. 175 mmHg, for vehicle vs. MS-PPOH, respectively.
[References]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Molecular Formula ]:
C16H25NO4S
[ Molecular Weight ]:
327.439
[ Exact Mass ]:
327.150421
[ PSA ]:
84.34000
[ LogP ]:
3.16
[ Index of Refraction ]:
1.517