dTAG-7

Names

[ CAS No. ]:
2064175-32-0

[ Name ]:
dTAG-7

Biological Activity

[Description]:

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

FKBP12(F36V)

BRD4

Cereblon

[References]

[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₃H₇₉N₅O₁₉

[ Molecular Weight ]:
1210.32

dTAG-7

Names

Biological Activity

Chemical & Physical Properties

Related Compounds