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BB-78485

Names

[ CAS No. ]:
207732-11-4

[ Name ]:
BB-78485

[Synonym ]:
(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide
N-Hydroxy-3-(2-naphthyl)-N2-(2-naphthylsulfonyl)-D-alaninamide
2-Naphthalenepropanamide, N-hydroxy-α-[(2-naphthalenylsulfonyl)amino]-, (αR)-
BB-78485

Biological Activity

[Description]:

BB-78485 is an LpxC metalloenzyme inhibitor with antibacterial activity. BB-78485 can inhibit LpxC with an IC50 value of 160 nM. BB-78485 can be used for the research of gram-negative selective antibacterials[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 160 nM(LpxC)[1]


[In Vitro]

BB-78485 可以抑制 LpxC，IC50 值为 160 nM[1]。 BB-78485 对 D21 和 D22 (lpxC101) 有作用，MIC 值分别为 2 μg/mL 和 0.016 μg/mL[1]。 BB-78485 对Enterobacteriaceae, Serratia marcescens, Morganella morganii, Moraxella catarrhalis, Haemophilus influenzae和 Burkholderia cepacia的 MIC 值范围为 1μg/mL 至 32μg/mL[1]。

[References]

[1]. Clements JM, et al. Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrob Agents Chemother. 2002;46(6):1793-1799.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C23H20N2O4S

[ Molecular Weight ]:
420.48

[ Exact Mass ]:
420.114380

[ LogP ]:
4.05

[ Index of Refraction ]:
1.700

Related Compounds