CXCR4 probe 1

Names

[ CAS No. ]:
2077985-50-1

[ Name ]:
CXCR4 probe 1

Biological Activity

[Description]:

CXCR4 probe 1 (compound 5) is a potent and specific CXCR4-targeted PET tracer with an IC50 value of 6.9 nM against CXCR4-specific antagonist peptide, TN14003. CXCR4 probe 1 has potential to be used as CXCR4-specific imaging probe to diagnose and monitor the prognosis of inflammatory diseases, CXCR4-positive tumors, and metastatic cancers[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> CXCR

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4

[In Vivo]

CXCR4 probe 1 displays preferential accumulation in lung metastatic tumors and specifically binds to CXCR4-positive stem cells in bone marrow[1].

[References]

[1]. Oum YH, et al. A benzenesulfonamide derivative as a novel PET radioligand for CXCR4. Bioorg Med Chem. 2020 Jan 15;28(2):115240.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₀₁₈FN₅O₄S

[ Molecular Weight ]:
502.59

CXCR4 probe 1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds