Cyclo(-Trp-Trp)

Names

[ CAS No. ]:
20829-55-4

[ Name ]:
Cyclo(-Trp-Trp)

[Synonym ]:
cyclo-(L-Trp-L-Trp)
cyclo(L-tryptophanyl-L-tryptophanyl)
cyclo(tryptophyl-tryptophyl)
Cyclo(L-Trp-L-Trp)
Fellutanine A
(3S,6S)-3,6-bis(1H-indol-3-ylmethyl)piperazine-2,5-dione
(3S,6S)-3,6-Bis(1H-indol-3-ylmethyl)-2,5-piperazinedione
c-(L-Trp-L-Trp)
3,6-Bis(1H-indol-3-ylmethyl)-2,5-piperazinedione
cyclo-L-tryptophan-L-tryptophan
2,5-Piperazinedione, 3,6-bis(1H-indol-3-ylmethyl)-
cyclo(Trp-Trp)
2,5-Piperazinedione, 3,6-bis(1H-indol-3-ylmethyl)-, (3S,6S)-

Biological Activity

[Description]:

Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Cyclo(L-Trp-L-Trp) can inhibit A. baumannii (MICs=12.5-25 µg/mL), as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus (MICs=12.5-50 µg/mL)[1].

[References]

[1]. Keyong Ho Lee, et al. Identification of Streptomyces sp. KH29, which produces an antibiotic substance processing an inhibitory activity against multidrug-resistant Acinetobacter baumannii. J Microbiol Biotechnol. 2010 Dec;20(12):1672-6.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
813.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₀N₄O₂

[ Molecular Weight ]:
372.420

[ Flash Point ]:
445.7±32.9 °C

[ Exact Mass ]:
372.158630

[ PSA ]:
89.78000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.724

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%