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(1R,1'S,3'R/1R,1'R,3'S)-L-054,264

Names

[ CAS No. ]:
208706-12-1

[ Name ]:
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264

Biological Activity

[Description]:

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor
Research Areas >> Neurological Disease

[References]

[1]. Yang L, et al. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9.  

[2]. Weir K, et al. A potential role for somatostatin signaling in regulating retinal neurogenesis. Sci Rep. 2021 May 26;11(1):10962. doi: 10.1038/s41598-021-90554-3. Erratum in: Sci Rep. 2021 Aug 16;11(1):16948.  

Chemical & Physical Properties

[ Molecular Formula ]:
C33H41N5O2

[ Molecular Weight ]:
539.71

[ Exact Mass ]:
539.32600

[ PSA ]:
103.25000

[ LogP ]:
6.15050

Related Compounds