JQ1-TCO

Names

[ CAS No. ]:
2087490-43-3

[ Name ]:
JQ1-TCO

Biological Activity

[Description]:

JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4


[In Vitro]

JQ1-TCO (10 μM; 18 h) 在 HeLa 细胞中不会诱导 BRD4 的显著降解[1]。

[References]

[1]. Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270.  

[2]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.  

Chemical & Physical Properties

[ Molecular Formula ]:
C31H37ClN6O3S

[ Molecular Weight ]:
609.18

Related Compounds