TMPRSS6-IN-1

Names

[ CAS No. ]:
2088415-78-3

[ Name ]:
TMPRSS6-IN-1

Biological Activity

[Description]:

TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Others

[Target]

TMPRSS6 (Matriptase-2)[1]


[References]

[1]. St-Georges C, et al. Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem. 2017 Mar 31;129:110-123.  

Chemical & Physical Properties

[ Molecular Formula ]:
C33H40N8O4S2

[ Molecular Weight ]:
676.85

Related Compounds