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Diprotin A TFA (Ile-Pro-Pro (TFA))

Names

[ CAS No. ]:
209248-71-5

[ Name ]:
Diprotin A TFA (Ile-Pro-Pro (TFA))

Biological Activity

[Description]:

Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase
Research Areas >> Metabolic Disease

[Target]

DPP-IV[1].


[In Vitro]

Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].

[In Vivo]

In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].

[References]

[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.


[Related Small Molecules]

Talabostat mesylate | Linagliptin | Teneligliptin | Vildagliptin (LAF-237) | AZD7986 | Omarigliptin | Anagliptin | Trelagliptin | Gemigliptin | DPP-IV-IN-2 | DBPR108 | Saikogenin A | UAMC 00039 dihydrochloride | Dutogliptin | Gosogliptin

Chemical & Physical Properties

[ Molecular Formula ]:
C19H32F3N3O6

[ Molecular Weight ]:
455.47

[ Storage condition ]:
2-8℃


Related Compounds