Diprotin A TFA (Ile-Pro-Pro (TFA))
Names
[ CAS No. ]:
209248-71-5
[ Name ]:
Diprotin A TFA (Ile-Pro-Pro (TFA))
Biological Activity
[Description]:
Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
[Related Catalog]:
[Target]
DPP-IV[1].
[In Vitro]
Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].
[In Vivo]
In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H32F3N3O6
[ Molecular Weight ]:
455.47
[ Storage condition ]:
2-8℃