CYP17-IN-1

Names

[ CAS No. ]:
2093317-51-0

[ Name ]:
CYP17-IN-1

[Description]:

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[Target]

IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]

[In Vitro]

CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].

[In Vivo]

CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].

[References]

[ Molecular Formula ]:
C₁₈H₁₇FN₂S

[ Molecular Weight ]:
312.40