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CYP17-IN-1

Names

[ CAS No. ]:
2093317-51-0

[ Name ]:
CYP17-IN-1

Biological Activity

[Description]:

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[Target]

IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]


[In Vitro]

CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].

[In Vivo]

CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].

[References]

[1]. Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17FN2S

[ Molecular Weight ]:
312.40


Related Compounds