PROTAC BET degrader-2
Names
[ CAS No. ]:
2093388-33-9
[ Name ]:
PROTAC BET degrader-2
Biological Activity
[Description]:
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
[Related Catalog]:
[Target]
IC50: 9.6 nM (BET in the RS4;11 leukemia cell line)[1].
[In Vitro]
PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].
[References]
[Related Small Molecules]
(+)-JQ1
|
GSK126
|
Tazemetostat (EPZ-6438)
|
Birabresib (OTX015)
|
A 485
|
Curcumin
|
ARV-771
|
ARV-825
|
I-BET762
|
BI 2536
|
GSK343
|
C646
|
3-Deazaneplanocin A (hydrochloride)
|
I-BET151
|
666-15
Chemical & Physical Properties
[ Molecular Formula ]:
C41H42N10O6
[ Molecular Weight ]:
770.84
[ Storage condition ]:
2-8℃