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E3 Ligand-Linker Conjugate 4

Names

[ CAS No. ]:
2093388-45-3

[ Name ]:
E3 Ligand-Linker Conjugate 4

Biological Activity

[Description]:

E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

E3 ligase[1].


[References]

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H23N3O3

[ Molecular Weight ]:
329.39

[ Storage condition ]:
2-8℃

Related Compounds